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The diverse mechanisms of action among agents such as tirzepatide, denifanstat, semaglutide, dapagliflozin, and efruxifermin highlight the complexity of MASH pathogenesis and the need for tailored treatment approaches

Another study indicated that irisin could attenuate inflammation induced by oxygen-glucose deprivation by inhibiting reactive oxygen species (ROS) and the NLRP3 inflammatory signaling pathway ( Irisin plays a significant role in macrophage polarization and its anti-inflammatory function

While GLP-1 RAs offer promising therapeutic outcomes, clinicians must address potential challenges, including gastrointestinal side effects, contraindications (e.g., pregnancy, severe GI disorders), and risks associated with improper compounding practices (48)(540)

doi: 10.15690/vramn.v69i9-10.1130 17 ClarkeG.StoneT