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Tirzepatide Clinical Evidence Context Tirzepatide has one of the largest clinical trial programs of any incretin drug

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Clinical trial results at a glance The clinical trial data around oral GLP-1s is already highly encouraging

Furthermore, efforts directed at generating combinatorial GLP-1R agonists with one or two additional peptide agonists to achieve greater weight loss (18) in a single molecule may need to consider the effect of molecular structure on the GLP-1Rdependent uptake and activity of the hybrid agonists in the CNS

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