Human trials employing standardized extracts (e.g., SHR-5) at doses ranging from 200 to 680 mg/day have reported a low incidence of adverse events, primarily mild and transient symptoms such as dizziness, dry mouth, or gastrointestinal discomfort
The patients other symptoms, including fatigue, neurological, gastrointestinal, and urinary, also showed complete resolution
GPxglutathione peroxidase
In addition to LPS, gut-derived metabolites such as short-chain fatty acids (SCFAs) can influence BBB function, with certain SCFAs promoting anti-inflammatory pathways that protect the integrity of the BBB (Ahmed et al., 2022)
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