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Compassionate care, physical and emotional support, and public awareness can make a meaningful difference in the lives of those affected

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In individuals with concomitant type 2 diabetes (T2D), weight loss reached 9.6% and 7% with semaglutide 2.4 mg/week and 1 mg/week, respectively, versus 3.4% with placebo [21]

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During oral glucose ingestion, GIP(3-30)NH 2 infusion reduces postprandial splanchnic blood flow in healthy men ( 3.8 Adverse effects of GIP receptor antagonism So far, no adverse effects have been reported with the administration of GIP receptor antagonists in humans or animals

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Patients should be encouraged to: Consume a balanced diet rich in calcium (dairy products, fortified plant-based alternatives, leafy greens) Ensure adequate protein intake to preserve lean muscle mass during weight loss Engage in regular physical activity following UK Chief Medical Officers' guidelines Limit alcohol consumption to no more than 14 units per week, spread over 3 or more days Avoid smoking, which impairs bone health Maintain safe home environments to reduce fall risk When to seek medical advice : Patients should contact their GP or diabetes specialist nurse if they experience unexplained bone pain, sustain a fracture from minimal trauma, or have concerns about their bone health

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