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Injection Site Sensitivity It is also worth noting where you are injecting your medication

The best GLP-1 for weight loss may indeed vary based on weight targets, with higher-efficacy options like tirzepatide preferred for significant weight reduction goals

Semaglutide works by: Slowing gastric emptying food remains in the stomach longer, promoting feelings of fullness Reducing appetite acting on brain receptors that regulate hunger and satiety Improving glycaemic control enhancing insulin secretion and suppressing glucagon release Promoting weight loss through reduced caloric intake Wegovy is administered as a once-weekly subcutaneous injection, with doses gradually increased over 16-20 weeks to minimise gastrointestinal side effects

Although RETA induced a significant reduction in fasted blood glucose concentrations after 1 week, which steadily rose over time but remained significantly reduced compared to Veh, RETA-w/d caused a sharp increase in fasting blood glucose (Fig