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The orally active AMPK activator 5-(3-(4-(2-(4-fluorophenyl)ethoxy)phenyl)propyl)furan-2-carboxylic acid [22] tended to increase levels of plasma total GLP-1 ( p = 0.07), but not of total GIP, to a lower degree relative to AICAR (ESM Fig

Proinflammatory cytokines, such as tumor necrosis factor-alpha (TNF-), interleukin-1 beta, and interferon-gamma (IFN-), promote ROS production, while ROS scavengers such as pyrrolidine dithiocarbamate and N-acetyl-cysteine (NAC) can reduce the ROS levels induced by these cytokines 14

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Vijatovic, M