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Experimental procedures were conducted in conformity with institutional guidelines (The Second Affiliated Hospital of Zhejiang University School of Medicine, Zhejiang, China) for the care and use of laboratory animals, and ethical approval was obtained from The Second Affiliated Hospital of Zhejiang University School of Medicine

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Age, sex, and metabolic health status also play roles, with some evidence suggesting that younger patients and those without significant metabolic comorbidities may respond more rapidly