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Clinical Study Report

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In addition to its direct effects on beta cells, GIP also leads to increased glucagon secretion, and indirectly results in increased insulin secretion via communication between the alpha and beta cells of the pancreas ( via complex mechanisms, including stimulation of somatostatin secretion, which inhibits glucagon secretion, and indirectly via stimulation of insulin production, which then inhibits glucagon release ( Figure 1 Incretin action plays a large role on post-prandial secretion of insulin, and may account for up to 70% of hormone release ( Both incretins have effects outside the pancreas

Lack of ongoing care Safe treatment requires follow-ups, dose adjustments, and side-effect monitoring

However, unlike endogenous GLP-1, which breaks down rapidly in the body, Sema has been chemically modified to be long-acting and resistant to enzymatic degradation