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You can read the abstract of this article at The high rate of failure in drug development is a significant problem, with only a small fraction of compounds successfully making it through the entire process and gaining regulatory approval

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The first line of the antioxidant defence system consists of antioxidant enzymes, such as superoxide dismutases (SOD: MnSOD, CuSOD, ECSOD), catalase (CAT) and glutathione peroxidase (GPx)

If your heartburn worsens or doesnt improve, regardless of what you try, seek medical advice from your healthcare provider