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Given the fact that many tumor-infiltrating CD8 + T cells are already anergic/exhausted, an alternative hypothesis is that the levels of GSH in the T cells are potentially more a consequence of the redox state of the hypoxic/reduced tumor microenvironment (TME) than a sign of T cell fitness, which remains to be tested

Sci., 252, 107249, 2023

This step has 5-hydroxy-L-tryptophan as substrate, pyridoxal 5-phosphate as an optional activator, and is influenced by Al 3+ , Zn 2+ , Ca 2+ , and Mg 2+ levels

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