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The FDA added a boxed warning to tirzepatide in June 2024, spotlighting severe gastroparesis risk but noting benefits outweigh harms

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Furthermore, in a BK5.IGF-1 mouse model of breast cancer, elevated levels of IGF-1 expression activated the COX-2/PGE2/EP3 signaling pathway, accompanied by increased VEGF expression and tumor angiogenesis (110)

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