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They slow gastric emptying, which can leave food in the stomach despite fasting, increasing the chance of aspiration during anesthesia

However, as with all insulin products, glucose monitoring should be intensified and the TRESIBA dosage adjusted on an individual basis in patients with hepatic impairment

Kidney Int 63(6):22802285 Wuerges J, Garau G, Geremia S, Fedosov SN, Petersen TE, Randaccio L (2006) Structural basis for mammalian vitamin B12 transport by transcobalamin