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[1] Dose-escalation studies, such as a 12-week trial on gradual titration, revealed that beginning at lower doses (e.g., 4 mg) and slowly increasing to therapeutic levels significantly reduced the incidence of nausea, vomiting, and diarrhoea

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According to the FDA prescribing information, these reactions vary by dose and product, typically manifesting as localized redness (erythema), itching (pruritus), swelling, or mild discomfort at the injection site