The Bile salt export pump (BSEP) and small heterodimer protein (SHP) are known targets of the FXR signaling pathway, and their transcriptional induction expression is regulated when the FXR signaling pathway is activated [284]
The Long N-terminal extension The Long prefix denotes a 13-amino-acid peptide extension fused to the N-terminus of the molecule
Acta Pharm Sin B 13:498516 Gaspar D, Freire JM, Pacheco TR, Barata JT, Castanho MA (2015) Apoptotic human neutrophil peptide-1 anti-tumor activity revealed by cellular biomechanics
Administration method: Subcutaneous injection, once a day, for 8 consecutive weeks
Generally, synthetic ATs appear to have more benefits over natural ones (indeed, they have been specifically developed to have improved properties compared to their natural counterparts)