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Glucagon-like peptide-1 (GLP-1) receptor agonists are medications that have been used to treat type 2 diabetes for years

The oncogenic effect of insulin could be due to the overexpression of insulin receptor by cancer cells, but also to its ability to interact with the IGF1 receptor, especially at supraphysiologic doses (Gallo et al., 2018) and with the use of long-acting analogues (Sciacca et al., 2010)

Yu ML, Chuang WL

A pragmatic way forward is to (i) use Bayesian inference to express uncertainty in clinically interpretable probabilities, and (ii) use data-driven phenotyping (including ML-enabled clustering where appropriate) to describe heterogeneity in treatment response

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