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[42] [43] El glutatin es un componente intracelular fuertemente regulado y limitado en su produccin debido a la inhibicin de retroalimentacin negativa de su propia sntesis a travs de la enzima gamma-sintetasa glutamilcistena

Over time, the brain reduces its own production of these chemicals to compensate, meaning that in the absence of alcohol, dopamine drops and anxiety rises, triggering a craving

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10.1016/S0166-2236(96)10074-6 Trends Neurosci