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However, when these mice are placed on a high-fat diet (HFD) the Glp1r/ animals are leaner than wild-type (WT) controls (Hansotia et al., 2013), a phenotype that goes against the role of GLP-1R signaling in the control of body weight
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These data indicate that there are a number of associated microstructural, cellular, and potentially even neuroregenerative changes associated with DTC stimulation that may provide the mechanistic underpinnings of this neuromodulatory therapy