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Dopaminergic pathways are similarly affected, with reduced tyrosine hydroxylase activity leading to diminished dopamine in the basal ganglia and prefrontal cortex, manifesting as anhedonia, reduced motivation, and psychomotor retardation (73, 74)

eLife 14 , RP106217 (2025)

| Hardik Pandya

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The process begins with a detailed review of symptoms, family history, and medication use to identify potential risk factors or other causes of cognitive decline