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The biggest impact of increasing flavanols, was seen in the COSMOS study, in those in the lowest third for dietary intake specifically seeing improvement in aspects of memory that link to the hippocampus, that central area of the brain that degenerates in Alzheimers (24)

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Notably, although in the study by Tan et al., C10 stimulated proton leak in cultured astrocytes, no increase in proton leak was registered in the mitochondria isolated from the hippocampus of the MCT-fed animals