Though most of these side effects do reduce once you have been taking the medication for a while, some side effects may persist or be intolerable
I started on Zepbound (tirzepatide acts on GLP and GIP receptors) in June 2025 and took it until April 2026, with more than 40 pounds gone (diet changes and exercise included)
During the segment, they specifically recommend that "if you're trying to lose weight, you want to stay with 90-10 ground beef, you want to stay with lean meats like bison." This protein-packed option helps trigger satiety hormones naturally while providing satisfying flavor with less fat than traditional beef
While weight loss itself can lead to improvements in psoriasis and HS, the benefits of GLP-1RAs appear to be from a combination of improvements in metabolic parameters as well as a direct anti-inflammatory effect, he says
Most significantly, the combined therapy of Vit C and CoQ10 displayed the highest efficacy in moderating these inflammatory markers