In vivo evidence for a lactate gradient from astrocytes to neurons
body mass index (BMI) of 21.033.0 kg/m 2 , sedentary lifestyle (defined by Stanford questionnaire, Additional file 1: Table S1), maintain current dietary habits and activity levels, if taking supplements agree to maintain dosing regimen for at least one month prior to baseline and during the study, agree not to start any new supplements, give voluntary, written informed consent to participate
The pathways that regulate GSH production and recycling are extremely complex [Figure 1], and most research on this system has been conducted through association studies which can suggest local mechanisms but cannot fully capture the interactions in the system as a whole
The incidence of MACE in patients with and without established CV disease was 13.4% in the BYDUREON group versus 14.6% in the placebo group and 6.0% (BYDUREON) versus 5.9% (placebo), respectively
This established semaglutide's cardiovascular safety profile and suggested potential protective benefits