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They require medical supervision, with NICE providing specific guidance on their use in type 2 diabetes (NG28) and obesity

The Forkhead Box m1b transcription factor is essential for hepatocyte DNA replication and mitosis during mouse liver regeneration

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In mild cases, discontinuation of the offending medication, sedation with benzodiazepines and supportive care is often sufficient, whereas in moderate SS, there needs to be more aggressive treatment of haemodynamic/autonomic instability with consideration of adding in a serotonin antagonist (such as cryproheptadine)