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Unless otherwise required, for the pathologies described above we request Whole Exome Sequencing (WES) with phenotype-directed analysis, a selected panel of blood-based biochemical markers, andwhere financially feasiblethe functional metagenomic analysis of the gut microbiome, which provides significant added value (Gilbert et al., 2018

These processes are interdependent and must function in coordination to prevent metabolic bottlenecks

This conversation should prioritize efficacy, safety, and personal access factors rather than manufacturer brand alone

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