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Notice that GSH goes up for low estradiol values, reaches a peak and descends for high estradiol values Variation of GSH steady state depending on S In our model, we take the activation of GCL and GPX by estradiol to be 80%, which is a reasonable choice supported by the experimental and clinical data discussed above

[19]Zulfiqar U, Farooq M, et al

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Treatment strategies with epigenetic enzymes, primarily targeting histone modifiers (such as histone deacetylase, 520 histone demethylase 521 and histone methyltransferase, 522 ) show therapeutic potential in animal models

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