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In addition, the incorporation of hyaluronic acid (HA) into HA@MOF/D-arginine facilitates its specific binding to cancer cells, enhances the radiosensitivity of osteosarcoma, and effectively prevents tumor recurrence, demonstrating both safety and efficacy [266]

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Contraindications against participating in melanotan research include a medical and family history of melanoma or other skin cancers, known allergies to melanotan, and severe hepatic and renal diseases

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