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The immune system further exacerbates ferroptosis in HT

Alcoxyl, peroxyl, hydrogen peroxide, and singlet oxygen [25], are byproducts that are deposited in the mitochondria, thereby making this organelle the main site for the generation of reactive oxygen species (ROS) within the cell and the first line of defense against oxidative stress [26]

ROS accumulation destroys the mitochondrial membrane and induces nerve deformation and cell apoptosis

Serum indoxyl sulfate associates with postangioplasty thrombosis of dialysis grafts

The phosphorylation of PDH inhibits its activity and, therefore, leads to decreased oxidation of pyruvate