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Vitamin C, vitamin E, selenium and zinc each have recognised roles in helping protect cells from oxidative stress, while vitamin C, selenium and zinc also contribute to the normal function of the immune system

Amino acid derivatives, Furthermore, aspartyl phenylalanine (Asp-Phe) could stabilize HIF-1 by competitively inhibiting prolyl hydroxylase (PHD), forming a metabolic-hypoxic positive feedback loop, while a small-molecule inhibitor targeting its synthetase, Phgdh, could reduce synovial thickness by 42% in a collagen-induced arthritis (CIA) animal model (81, 82)

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