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On the one hand, excess iron ions can directly catalyze ROS production, exacerbating oxidative stress, while also promoting the generation and aggregation of A and catalyzing the hyperphosphorylation of the tau protein

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For more information, read this article which looks at the connection between thiamine deficiency and small intestinal bacterial overgrowth: When Sibo & Ibs-Constipation Are Just Unrecognized Thiamine Deficiency Thiamine also exerts direct effects on the intestinal barrier