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While these clinical trials have shown that semaglutide can lead to significant weight loss, it is important to note that the medication is not a substitute for a healthy diet and regular exercise

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Hyperuricemia continues to be inadequately managed, primarily due to factors such as ineffective dosing of urate-lowering therapy, patient noncompliance, and intolerance/adverse events associated with current treatment options

The degree of improvement depends on the severity of laxity and individual skin quality

Cell (2016) 165:80111