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How a First-in-Human Trial Works First-in-Human trials are generally conducted in highly controlled clinical environments such as specialist clinics or hospital settings designed to ensure continuous participant monitoring and rapid intervention if necessary

The aims of this review are (1) to provide an overview of the clinical and biological overlap between neuropsychiatric long COVID and other fatigue-associated neuropsychiatric disorders, (2) to examine the shared molecular mechanisms of fatigue and depressive symptoms involving acetylcarnitine metabolism, and finally (3) to review the current evidence on acetylcarnitine supplementation studies as a treatment for fatigue-associated syndromes and pharmacological aspects of acetylcarnitine supplementation to provide a conceptual foundation for acetylcarnitine supplementation in neuropsychiatric long COVID syndrome

Nature Rev Genet

O.SongY.LuoQ.QiaoT.et al

Patoulias D, Boulmpou A, Papadopoulos CE, Doumas M