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Bodybuilders and athletes have explored IGF-1 DES for "targeted" muscle development in lagging body parts, though such applications raise ethical and safety questions

[DOI] [PMC free article] [PubMed] [Google Scholar] 286.Mendell J.R., Al-Zaidy S., Shell R., Arnold W.D., Rodino-Klapac L.R., Prior T.W., Lowes L., Alfano L., Berry K., Church K., et al

Ill be diving into this BIG debate with my esteemed Endocrinologist colleague A/ Prof Erosha Premaratne where we explore: Why bariatric surgery still delivers the most durable weight loss outcomes How surgery catalyses behavioural transformationnot just biological changes The emerging synergy between GLP-1s and surgical interventions What the STEP & SURMOUNT trials dont fully reveal As someone who works on the frontlines of metabolic health, my stance is clear: GLP-1s are a breakthrough, not a replacement

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