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NICE TA875 confirms that gastrointestinal (gut) side effects are expected with semaglutide and recommends a gradual dose escalation to minimise discomfort

NCT01037582: The first-in-human, single dose, safety study of oral semaglutide was conducted on 135 healthy male persons, who received 220 mg of oral semaglutide (220 mg) prepared with SNAC (150600 mg)

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It found that those taking semaglutide saw greater improvements in body composition and testosterone levels