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Under hypoxic conditions, L-2-hydroxyglutarate (L-2-HG) was proven to be generated by lactate dehydrogenase A (LDHA) and malate dehydrogenase (MDH) 88,89

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doi: 10.1210/er.2011-1052 14 DuringMJCaoLZuzgaDSFrancisSJFitzsimonsHLJiaoXet al