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Activation of GLP-1R also triggers the PI3K/Akt signaling pathway via the subunits of G proteins, thereby promoting -cell viability and replicative capacity ( 2.2 Inflammation and immune modulation Recent preclinical studies have demonstrated its bidirectional immunomodulatory effects, including improvement of organ dysfunction, regulation of immune responses, and mitigation of sepsis-associated cytokine storms, mediated through anti-inflammatory and anti-apoptotic pathways

Reagan-Shaw, S., Nihal, M

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[5] Adrenal Dysfunction Adrenal dysfunction (also known as adrenal fatigue ) can result from an overloaded immune system (as explained in the Immune Overload section above), as well as from imbalances in cortisol production and steroid levels