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The importance of mitochondria extends beyond adenosine triphosphate (ATP) production to roles in calcium buffering, redox homeostasis, and coordination of innate immune signaling pathways (Stewart and Chinnery, 2015)

In the lab, it has been investigated extensively in animal and cell models for its purported regenerative, cytoprotective, and angiogenic effects

2020 Jun 24;10:100126

479 Another cascade linking astrocytes to the pathophysiology of Down syndrome is an increased production of hydrogen sulphide, which is catalysed by cystathionine--synthase expressed, more or less exclusively, in astrocytes, and upregulated in a rat model of the disease

Cui L, Fan J, Sun Y, Zhu Z, et al