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However, it is also associated with significantly greater odds for treatment discontinuation, due to gastrointestinal adverse events, mainly nausea and vomiting. Researchers searched the PubMed and Cochrane Library databases up until Feb

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Prespecificed renal outcomes, including progression of albuminuria and a renal composite (40% reduction in estimated glomerular filtration rate, need for renal replacement therapy, or death from renal causes), while not statistically significant, showed the potential benefit of canagliflozin that was further studied in the CREDENCE trial