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Statistical analysis was performed using IBM SPSS Statistics, version 27.0 (IBM Corporation, Armonk, New York, USA)

This material may present a threat to the tolerization of B cells and T cells

Proteins associated with the ribosome and rRNA binding were upregulated in HFpEF animals treated with semaglutide, while pathways related to the inflammatory response, oxidative phosphorylation, and SNARE proteins were downregulated ( Figure S10 )