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However, prolonged discontinuation may compromise glycaemic control and cause rebound appetite

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Gabapentinoids as First-Line Treatment gabapentin (Neurontin, Gralise) gabapentin enacarbil (Horizant) pregabalin (Lyrica, Lyrica CR) Most patients tolerate these medications well, says Alon Avidan, MD, MPH, professor of neurology at UCLA and director of the UCLA Sleep Disorders Center in Los Angeles

The digestive system and other metabolic processes can break down these compounds before they reach their intended targets

Pigmentation without appetite suppression suggests the compound is binding MC1R (melanocytes) but not effectively crossing the blood-brain barrier to reach MC4R (hypothalamus)