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Abstract In healthy humans, the incretin glucagon-like peptide 1 (GLP-1) is secreted after eating and lowers glucose concentrations by augmenting insulin secretion and suppressing glucagon release

GLP-1 medications like semaglutide are available on the NHS only through specialist weight management services if you meet strict criteria: typically BMI 35 kg/m with at least one weight-related comorbidity such as type 2 diabetes or hypertension

The mitochondria and endoplasmic reticulum (ER) are critical sources of ROS and lipid peroxidation products

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Marx N, Husain M, Lehrke M, Verma S, Sattar N (2022) GLP-1 receptor agonists for the reduction of atherosclerotic cardiovascular risk in patients with type 2 diabetes