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Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1

Therefore, we assessed 39 mainly functional polymorphisms in genes involved in inflammation, in particular the NFB pathway, in a cohort of 738 Danish IBD patients previously naive to anti-TNF therapy

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472 The right hippocampus, parahippocampal gyrus, left amygdala, and the whole caudate nucleus all had functional changes in activity in MDD patients compared to healthy controls, indicating that the temporal lobe might be involved in the pathogenesis of MDD