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A 2010 paper in Annals of the New York Academy of Sciences by Goldstein et al

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For example, pairing GLP-1 with glucagon aims to merge GLP-1s strong appetite-suppressing and glucose-lowering effects with glucagons lipolytic and thermogenic actions (possibly mediated indirectly through factors such as FGF21)

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Both stacks pair retatrutide with a second compound that addresses a different limit

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