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The HRs comparing tirzepatide versus controls were 0.80 (0.571.11) for MACE-4

What can we reasonably conclude from this conflicting data

When GLP-1 Muscle Loss Can Become Muscle Wasting Malnutrition Risks While moderate lean-mass reduction during weight loss is a normal adaptive process , true muscle wasting can occur if the body becomes undernourished

Semaglutide is a revolutionary GLP-1 receptor agonist that was originally developed for patients with Type 2 diabetes, but when providers and pharmaceutical developers noticed how much weight their patients were losing, they began to study semaglutide exclusively for weight loss

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