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Recent convergence of artificial intelligence (AI) and big data analytics has presented unprecedented opportunities to address these translational barriers by large-scale, high-dimensional profiling of molecular, clinical, and lifestyle information (252)

CHF, Chronic heart failure

This step might involve acid-base catalysis by the active-site cysteinyl thiolate (which could explain an effect of the second cysteinyl residue), and/or the conserved lysine residue, yielding GS in analogy to glutathione transferases (Fig

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Korshunov and Imlay, 2024)