Cowley, A
Lactate produced by aerobic glycolysis in cells suffering from chronic hypoxia is a so-called oncometabolite implicated in tumor epigenetic regulatory activity, tumor angiogenesis, and lipid metabolisms favoring anabolic and catabolic activity in the tumor (de la Cruz-Lpez et al., 2019
Transdermal drug delivery isn't new nicotine patches, hormone therapies, and nitrate medications have been crossing the skin barrier for decades
Known medications associated with oral melanosis include tranquilizers, antibiotics, antifungals, antimalarials, arthritis medications, and hormone therapy medications
Increased Fas expression in thyrocytes has been documented in HT, indicating that programmed cell death can be initiated via an externally triggered mechanism (Kotwal et al., 2020)