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Conclusions and Lessons Learned The potential of DPP-4 inhibition as a glucose-lowering concept has now been explored for more than 25 years and it is more than 10 years since several DPP-4 inhibitors were introduced to the market (Figure 1)

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Using the well-characterized 143B mitochondrial cybrid model 50 , we demonstrated that mtDNA mutant cells are more sensitive to 5FU treatment (Fig

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