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Long-term semaglutide users (beyond 8 weeks of treatment) who have adapted well to their medication usually tolerate 12 cups of coffee daily without compromising weight loss results or medication efficacy

And some people have fewer side effects on one drug versus another

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In addition to improving insulin resistance, metformin can also alleviate cellular autophagy via regulating the PI3K/AKT/mTOR pathway to improve ovarian function

This combination is increasingly prescribed by weight loss specialists, though it requires careful medical oversight