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The mutants were characterized by their ability to bind GLP-1 and exendin-4, using the agonist 125 I-GLP-1 tracer, and by their ability to stimulate cAMP production in response to GLP-1 and exendin-4 (Table 2)

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Currently CKD affects more than 800 million people [3] and it is estimated that by 2040, it will be the 5th highest cause of years of life lost globally due to the aging population and the rising prevalence of age-related diseases such as hypertension and diabetes [4]

JL: Data curation, Methodology, Writing original draft

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