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FFA accumulation in liver results in lipotoxicity by enhancing superoxide anion generation via NADPH oxidase and mitochondrial respiratory chain [3]

PLoS One 10:e0140963

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Hou L, Honaker MT, Shireman LM, Balogh LM, Roberts AG, Ng KC, et al

Consequently, numerous therapeutic strategies have begun to target the ferroptosis pathway, particularly in the design and development of nanodrug delivery systems (NDDSs)