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WADA Prohibition The World Anti-Doping Agency has addressed MOTS-c in anti-doping guidance: While not explicitly listed by name in current prohibited substances lists, would likely fall under non-approved substances (Section S0) Detection methods under development for anti-doping testing programs Use by competitive athletes prohibited under WADA Code Exercise-mimetic properties create performance enhancement concerns USADA guidance specifically warns athletes that MOTS-c is not approved by FDA and remains prohibited for competitive sport use

Differential methylation has been observed in the genes of several oncogenic pathways in PTC [148, 149]

Limited experience in patients: aged 85 years or more

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2012 Wolfe RR et al