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SLC7A11 blockade and APR-246 synergize to kill mut-p53 tumours Since APR-246 depletes GSH and system x C blockade leads to cystine starvation, which in turn impairs GSH synthesis, we hypothesized that their therapeutic combination would synergistically target mut-p53 cancer cells

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However, higher-risk patientsincluding those with active gastrointestinal symptoms, recent dose increases, gastroparesis, or obesity with GERDmay be advised to stop once-weekly injectable semaglutide approximately one week before the procedure based on individualized evaluation by their surgical team

3.3.2 Dulaglutide DUL is a long-acting GLP-1R agonist which can promote insulin secretion, inhibit gastric emptying, and reduce appetite

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